This non-invasive diagnostic method makes it convenient for prostate cancer patients as it utilizes urine thus, minimizing the need for invasive
and side effects. But as the concentration of cancer factors (a cancer-related biological index) remains low in urine, the urine-based biosensor is so far used to classify the risk groups than accurately diagnosing the patients.
The research team deployed different types of cancer factors using the electrical-signal-based
rather than employing only one factor to enhance the diagnostic accuracy innovatively to over 90%.
‘A new electrical-signal-based ultrasensitive biosensor can diagnose prostate cancer from the urine within twenty minutes with almost 100% accuracy. Utilizing a smart Artificial Intelligence (AI) method allows analyzing the intricate patterns of cancer factors in urine samples and deriving the diagnosis.’
This ultrasensitive semiconductor sensor system can simultaneously measure trace amounts of four selected cancer factors in the urine and provide a diagnosis for prostate cancer.
“For patients who need surgery and/or treatments, cancer will be diagnosed with high accuracy by utilizing urine to minimize unnecessary biopsy and treatments, which can dramatically reduce medical costs and medical staff’s fatigue,” says Professor Jeong at Asan Medical Center
The team trained an AI algorithm for identifying the correlation between the four cancer factors and analyzing their complex patterns of the detected signals to provide the diagnosis from the developed sensor. The AI analysis was able to detect 76 urinary samples successfully with almost 100 percent accuracy.
“This research developed a smart biosensor that can rapidly diagnose prostate cancer with almost 100 percent accuracy only through a urine test, and it can be further utilized in the precise diagnoses of other cancers using a urine test,” says Dr. Lee at the KIST.
Top AI Applications in Healthcare
The top applications of artificial intelligence that could change healthcare include:
- Hojun Kim et al, Noninvasive Precision Screening of Prostate Cancer by Urinary Multimarker Sensor and Artificial Intelligence Analysis, ACS Nano (2020). DOI:10.1021/acsnano.0c06946